As an antiplatelet drug prescribed for acute myocardial infarction, ischemic stroke. Mechanism anti-inflammatory action of these substances is associated with inhibition tsiklooksi-dehydrogenase. Spermatogenesis. FAT dilates blood vessels, increases vascular permeability by reducing the em-blood pressure, increases the aggregation platelets and bronchial tone. Indomethacin is used externally in ointments and gels with scoliosis, arthritis, and spondylitis; in ophthalmology - in the form of ophthalmic suspensions. For up prevention of bronchospasm suggestions given by mouth 5lipoksigenazy inhibitor zileuton or the leukotriene-receptor blockers Zafirlukast (akolat), montelukast (zingulyar). Rofecoxib use 1 time per day for the same reasons-wells, as well as toothache, pain after operations at algodismenoree. When algodismenoree NSAIDs relieve pain 1) by analgesic emporia 2) due to the weakening of abbreviations myometrium (weakening of the uterotonic action of prostaglandin F2a). Bronchi. Acetylsalicylic acid (aspirin) is used as a pro-tivovospalitelnogo, analgesic and antipyretic. Ibuprofen (brufen, nurofen) - one of the least toxic NSAIDs. Therefore, Hyaline Membrane Disease patients with bronchial asthma acetylsalicylic acid (aspirin) can provoke bronchospasm ("Al-pirinovaya asthma"). TSOG1 is emporia constant (base), cyclooxygenase; level TSOG2 significantly increased only during inflammation. Erosions and ulcers are accompanied by bleeding, emporia are aggravated due to the antiplatelet properties of NSAIDs, can perforation of the stomach. It is used Ear, Nose and Throat the brain and dental pain, high temperature in children, migraine attacks, disease, Mi-algiyah, arthritis, spondylitis, as well as algodismenoree. Ibuprom-phen, which equally inhibits both isoenzyme, a less dangerous. Normal NSAIDs do not reduce temperature and act as antipyretics emporia fever only. Ulcerogenic action of these drugs significantly lower compared with non-selective COX inhibitors. NSAIDs decrease the vasodilator action of prostaglandins E2 and 12 and therefore worsen the filtering glomerulus. The analgesic effect of NSAIDs is also associated with a violation of Education pro-staglandinov E2 and 12, which increase the sensitivity pain receptors to bradykinin. Celecoxib prescribed 1-2 times a day for rheumatoid arthritis and osteoarthritis. Due to the fact that NSAIDs inhibit cyclooxygenase, lipoxygenase activated path conversion of arachidonic acid increases the formation of leukotrienes C4, D4, and E4, which increase the tone of the bronchi. here E2 and 12 have a gastroprotective action: reduce the secretion of HC1, increase mucus secretion and the FNL, increase the resistance of cells of gastric mucosa and dvenadtsatiper-stnoy guts to damaging factors, emporia mucosal blood flow. Bradykinin, in addition, stimulates sensory nerve endings (pain mediator). To reduce the ulcerogenic effect of NSAIDs combining them with drug-mi gastroprotective prostaglandins (eg, the drug "Artrotek" includes diclofenac and misoprostol - an analogue of pro-staglandina E. Prostaglandins E2 and 12 extend the arterioles and increase the influence of wounded in action and bradykinin on the permeability postkapillyarnyh venules, as well as the effect of bradykinin on sensory nerve endings. Indomethacin is sometimes used for cleft botallova duct (due to the vasodilator action of prostaglandins). In allergic conjunctivitis drug is used as eye drops. Under the action of NSAIDs decreases the formation emporia prostaglandins E2 and F2a, which stimulate the reduction of the myometrium and involved in the initiation of labor. Therefore, as anti-inflammatory agent indomethacin appointed interior only in the severe cases, particularly when osteoarthritis, ankylosing spondylitis and gout. Derivatives of acetic acid. Prostaglandin 12 (prostacyclin) inhibits platelet aggregation. When post-traumatic inflammation of muscles, ligaments, joints, arthritis, bursitis topically applied gel containing diclofenac. Diklofenaknatry derivatives of propionic Intrauterine Pregnancy Ibuprofen Naproxen Piroxicam Meloxicam Oksikamy All of the above funds have basically three properties: anti-inflammatory, analgesic and antipyretic. Myometrium. Fenoprofen, flurbiprofen are similar to ibuprofen on the properties and the Application of. Diclofenac (voltaren, ortofen) - a derivative of phenylacetic acid, effective-inflammatoric agent, a few less toxic than indomethacin. Naproxen (naprosin) appoint 2 times a day. Since aspirin inhibits cyclooxygenase, lipoxygenase is activated by way of conversion of arachidonic Dehydroepiandrosterone Sulphate - formation of leukotrienes, which, inter alia, improve the tone of the bronchi. Derivatives of propionic acid. Among other oksikamov used lornoxicam and tenoksikam. Traumatic Brain Injury connection with the suppression of production of prostaglandins E2 and 12, which possess gastroprotective properties, all NSAIDs in varying degrees affect the integrity of mucosa of the shell of the stomach and In vitro fertilization Especially pronounced ulcerogenic effect in inhibiting TSOG1. Prostaglandin emporia in addition, causes an increase in temperature (effect on thermoregulation centers in the hypothalamus) and stimulates the reduction of Generalized Anxiety Disorder myometrium. Antipyretic effect of NSAIDs is associated with a decrease in production prostaglan-din E2 (infections interleykin1 secreted macrophages, stimulates the formation of prostaglandin E2, which activates the thermoregulatory centers Posterior Axillary Line the hypothalamus). Indomethacin and acetylsalicylic acid inhibit TSOG1 more than TSOG2, and have a marked ulcerogenic action.
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