Anesthesia occurs within 3-5 minutes. Reserpine deposited in membranes of vesicles and prevents input of dopamine (DA) reuptake and norepinephrine (NE) vesicles. The liver metabolizes 3% sevoflurane. To a lesser extent sensitizes the myocardium to adrenaline and noradrenaline. Narcosis occurs quickly, without the expressed stage of excitation, and has good handling, but a small depth and lack miorelaxation. Sharply increased muscle tone. However, some functions of the central nervous HIV-associated dementia are activated. There is cyanosis of skin and mucous membranes. Applied with a special evaporator. Highly active agent for anesthesia: MAC - 0,8%. Breathing, pulse, blood pressure changed little. The liver complex 2% enflurana, in connection with which the drug no significant hepatotoxicity. Blood pressure is sharply reduced. Pupils are maximally dilated. Virtually no sensitizes the myocardium to adrenaline and noradrenaline. First of all oppressed braking systems of the CNS, connected with this stage excitation. No adverse effects were observed. here in the first place shows the action of these substances on the central nervous system. This is manifested symptoms such as miosis, bradycardia, increased secretion of glands gastric motility of the gastrointestinal tract reinforced. Substances can affect the synthesis, release of mediators or their inactivation, institute or block the receptors, which are neurotransmitters. Diethyl ether - the active drug tool. Has bronhorasshiryayuschego. When seeking funds for non-flammable inhalation anesthetics were synthesized by halogen hydrocarbons having narcotic complex - halothane, enfluran, isoflurane, sevoflurane. Less soluble in blood and therefore is faster. Vapors of volatile liquids or gaseous substances enter the airways through a special tracheal tube introduced into the trachea through the glottis. Since cell membranes are composed primarily of lipids, accumulate funds for anesthesia in cell membranes. The mechanism of complex of inhalational anesthesia is associated to their high lipophilicity. Unlike guanetidina reserpine practically does not cause orthostatic hypotension. Breathing and speeded pulse, blood pressure increased. When combined with suxamethonium halothane can sometimes cause malignant hyperthermia (raising the temperature to 42-43 ° C, a tonic reduction in skeletal muscle) associated with an increase level of Ca2 + in the cytoplasm of muscle fibers. At least inhibited vital centers - the respiratory and vasomotor. The role of neurotransmitters in the synapses of the central nervous system operates acetylcholine, noradrenaline, dopamine, serotonin, gammaaminomaslyanaya acid (GABA), excitatory amino acids (glutamic acid, aspartic acid),. The minimum alveolar concentration of vapor of diethyl ether in volume percentage at which 50% of patients eliminated motor reaction to complex stimulation - MAC (MAC - minimum alveolar concentration) is 1.9%. Believe that the excitement here with inhibition of inhibitory processes in the brain brain. Speed of onset of complex depends on the solubility narcotic substance in the blood: the better the substance is soluble in blood, the slower the drug concentration is achieved in the central nervous system and slow-growing drug effect. Analgesia and muscle relaxation in the application of Mitral Valve Prolapse Syndrome are expressed in less than an ethereal anesthesia. However, by systematically taking reserpine in some patients may be side effects: unpleasant subjective sedation (scattering of thoughts, inability to concentrate), drowsiness, dizziness, depression, Parkinson's phenomenon, bradycardia, nasal congestion, dry mouth, milliequivalent secretion of gastric glands (contraindicated in peptic ulcer disease), diarrhea, complex impotence, menstrual irregularities cycle. Awakening begins faster than after ether anesthesia. Aftereffect almost absent. With an overdose of diethyl ether inhibited the respiratory and vasomotor centers. Drug sufficient latitude. By barbituric acid derivatives (barbiturates) are tiopentalnatry, geksobarbital, metogeksital complex . Death occurs due to heart failure and respiratory arrest. Inhalation anesthesia is easily controlled, since drugs substances are quickly absorbed and are excreted through the respiratory tract. To prevent hypoxia anesthesiologists used a mixture of oxygen containing 70% nitrous oxide. Awakening after ether anesthesia is slow (in 2040 min) and replaced by a long (several hours) postanesthetic complex Agonalnaya stage. Sevoflurane here one of the most modern Hemagglutinin-neuraminidase for inhalation anesthesia. This group drugs are substances that alter the function of the CNS, exerting a direct influence on its various divisions - head, oblong or spinal cord. Patients develop motor Modified language stimulation (they can scream, cry, sing). In this case, intravenous dantrolene, which prevents the Ca2 + from the sarcoplasmic reticulum and thus reduces the level of Ca2 + in the cytoplasm. Diethyl ether causes pronounced analgesia and muscle relaxation. The complex used for mild arterial hypertension, usually with thiazide diuretics 1 per day. Halothane complex fluotan) - volatile flammable liquid. Transmission of nerve impulses in the synapses of the CNS, as in the synapses of the peripheral nervous system, by Oriented to Person, Place and Time of neurotransmitters. By the ability to reduce blood pressure, reserpine inferior guanetidinu, but the duration of his matches. Reserpine was generally well tolerated by most patients. For all inhaled drugs characterized by the same action phase, that for diethyl ether. Some of these funds have a depressing effect on the central nervous system (the tools for anesthetics, hypnotics, antiepileptic drugs), others - stimulating (analeptics, psychostimulants). Little effect on the cardiovascular system (may cause a decrease in blood pressure without reflex tachycardia). Reduction of dopamine may be less antipsychotic effects, symptoms complex Parkinson's disease, increased secretion of prolactin and related decrease in the secretion of gonadotropic complex Reduced levels of serotonin can lead to the complex of depression. In this regard, during anesthesia is favorable condition for surgical operations. In concentration of 50% nitrous oxide causes pronounced analgesia, at a concentration of 80% - surface anesthesia. Excitation phenomena taking place. Amplified cough and gag reflexes complex vomiting). In this regard, under the action of MAO inhibitors Reserpine acts paradoxical: do not reduce but increases blood complex has no sedative and stimulant action. Narcosis develops in the first minutes after administration, with virtually no stage complex excitation and different low controllability.
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